A giant lizard has been spotted in the subways and Jameson is willing to pay $1,000 to the photographer who gets the creature on film. Peter turns to his college professor, Dr. Curt Connors, for answers. But not the answers he expects.
After Tony Stark eliminates Dr. Ohn’s research on dimensions, Ohn makes a deal with the Kingpin. After a malfunction in his new lab, Ohn is sucked into another dimension and becomes a powerful being, know as The Spot.
Doctor Octopus and Kingpin break Felicia’s father, John Hardesky aka The Cat, from prison. As a boy, The Cat witnessed the creation of Captain America and knows the formula they used. Now Kingpin wants the information for himself.
Spider-Man is becoming attached to his new suit. But Eddie Brock has framed Spider-Man for the Promethium X robbery. Alaster and Kingpin send Shocker after Eddie to dispose of him. Now, Spidey will begin to see what the suit is really worth.
Five of the Forgotten Six reunite and team up with Spider-Man to stop the Kingpin from activating the Dooms Day Weapon. But during the process of activating it, Captain America and Red Skull are returned.
Baron Mordo is back. He is planning to steal Tony Stark’s technology on dimensions so that he can bring the being known as Dormammu to Earth. But he will also need the help of Spider-Man’s greatest enemy: Venom.
Spider-Man seeks help from Prof. Xavier and his X-Men about the mystery behind his own mutation. Beast advises him to hear Herbert Landon’s presentation for a cure on mutation. But unknown to everyone, Landon’s new cure is actually meant to kill mutants instead.